Scientists have found that some diagnostic tools are not accurate enough when it comes to children with impaired kidney function, according to a study published in the Journal of Applied Laboratory Medicine.
The paper "Renal Function Influences Diagnostic Markers in Serum and Urine: A Study of Guanidinoacetate, Creatine, Human Epididymis Protein 4, and Neutrophil Gelatinase–Associated Lipocalin in Children" shows that diagnostic disease markers may be influenced by the renal function.
Impaired kidney function is a condition when your kidneys are unable to work properly. The kidneys are important organs in the body. Among their multiple functions, the most important function of the kidneys is to filter blood and producing urine, removing waste products from the blood and regulating the water fluid levels. Additionally, the kidneys also produce hormones and absorb minerals.
A variety of factors can lead to impaired kidney function, including diseases such as diabetes, high blood pressure, or heart disease, certain drugs such as stomach medicine and laxatives, drinking alcohol, and smoking.
In this study, the researchers set out to "investigate the effect of measured glomerular filtration rate (GFR) on 4 diagnostic markers in blood and urine—guanidinoacetate (GAA), creatine (CRE), human epididymis protein 4 (HE4), and neutrophil gelatinase–associated lipocalin (NGAL)." A total of 96 children with different stages of chronic kidney disease were enrolled in the study.
The study is led by resesarchers from University of Oslo in collaboration with University of Oslo, Oslo University Hospital, University of Bergen, and Haukeland University Hospital in Norway. (Cusabio offers HE4, NGAL, and Recombinant Aoc3 proteins.)
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