Flu virus kills a large number of people each. Finding effective vaccines is of great significance. Described in Nature Medicine, a new research led by Prof. George Georgiou from The University of Texas provides new insight into the process that flu vaccine induces production of protective antibodies against flu virus. This work indicates there is way to promote the effect of traditional flu vaccine.
The study reveals that quadrivalent flu vaccines, which are relativley expensive, might not provide significant benefits over trivalent flu vaccines, and that certain antibodies are able to fight agaisnt multiple stains of the virus.
There has been detection tools to help identify whether an indivisual has antibodies against a harmful microbe. However, the quantities and identities of the antibodies remain unclear. With the help of a novel technique known as Ig-Seq, the team were able to to directly identify and quantify antibodies in bloodstream.
Understanding the effiancy of existing vaccines will help to design more potent vaccines. First of all, it is necessary to determine which antibodies attach to the pathogen, and how exactly these antibodies work. Georgiou and colleagues examined the serum antibody repertoire in young adult people before and after seasonal flu vaccination, and found that just 40% of flu-specific antibodies were elicited by the vaccine, meaning that the 60% already existed before.
The team also identified some antibodies that were capable of rotecting experimental mice against lethal challenge by influenza but these antibodies were not working by preventing the virus from infecting cells, demonstrated an alternative mechanism that vaccine elicits beneficial effects. If you need Biotin conjugated antibody or other antibodies, contact CusAb.
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